Terms and conditions of storage
Nolvadex (Tamoxifen) preserves its therapeutic properties at normal room temperature. The main thing you should do is to prevent drug exposure to sunlight. Also, make sure that children have no access to medicine. The manufacturer recommends using Tamoxifen within 5 years from the moment it was released. Using an expired drug is unsafe.
|Drug Name||Doses||Per Pill||Visit Pharmacy|
|Generic Nolvadex||20 mg, 10 mg||$0.64|
|Generic Nolvadex||20 mg, 10 mg||$0.42|
Nolvadex is an antitumor agent. The main active component of the drug, Tamoxifen (non-steroid estrogen antagonist), was invented back in the 1960s. It can block estrogen receptors located on the surface of tumor cells. Over more than half a century of its use, this drug was considered one of the safest and the most effective remedies for fighting breast cancer.
Binding to the estrogen receptors, Tamoxifen paves its way to the tumor cell nucleus. There, it manages to block the activity of the female hormone, which, as we know, is an important component of the reproduction process of malignant cells. As a result, the tumor stops growing. A single-use is accompanied by a 2-3-week activity of the main component.
Nolvadex (Tamoxifen) is well absorbed from the digestive tract. The full absorption comes after 4-7 hours. The drug binds to plasma proteins by almost 100%. In the liver, Tamoxifen is subject to hydroxylation and demethylation, during which the active metabolites are formed. The drug is mainly excreted from the body in bile, and to a lesser extent — via the urine.
Indications and contraindications
Nolvadex is highly effective against:
- Breast cancer — it is used as part of adjuvant treatment of lymphatic and metastatic diseases.
- Endometrial cancer.
- Anovulatory infertility.
- McCune–Albright syndrome (genetic disease).
The use of Nolvadex is excluded in the following cases:
- Intolerance to the drug components.
- Severe thrombocytopenia and leukopenia.
- High blood calcium.
The decision to buy Nolvadex (Tamoxifen) must be based only on the appropriate medical advice. The price of self-medication in case of severe diseases can be very high.
Possible side effects
Nolvadex is a potent antiestrogen, which can cause serious adverse reactions. However, compared to other drugs of this class, it causes less severe complications (subject to close medical supervision). The most frequent side effects include:
- Increased risk of thrombophlebitis.
- Pulmonary embolism.
- Weight loss.
- Water retention.
- Intermenstrual bleeding.
- Clouding of consciousness.
- Hepatic pathologies.
- Obstructive jaundice.
- Violation of spermatogenesis.
- Uterine fibroids.
Some adverse reactions don’t require any action, while in other cases, qualified medical care is required to relieve the toxic effect.
Methods of application and dosage regimen
Only an experienced specialist can recommend you to buy Nolvadex for the treatment of cancer. The pills should be swallowed whole, without damaging their shell. Drink a small amount of still water.
The dosage is calculated depending on the disease. Patients with breast, endometrial, and kidney cancer must take 20-40 mg of the drug orally twice a day. Usually, the course has a longer duration (especially in case of metastasis) and stops when the positive dynamic or intolerant toxicity appears.
Features of use
During the therapy with Nolvadex (Tamoxifen), you should exclude the consumption of alcohol completely, particularly in the case of concomitant cardiovascular diseases. The male liver is under double attack, as both testosterone and Nolvadex make it work more actively. If you add an influence of alcohol, it can lead to the toxic effects, which must not occur during the treatment with Nolvadex.
Female patients should be under close gynecological control due to the possible risk of hemorrhage. In the event of this pathology, the drug should be discontinued. The same is true for deep vein thrombosis.